Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation

[Image: see text] Monopolar spindle 1 (Mps1) is an attractive cancer drug target due to the important role that it plays in centrosome duplication, the spindle assembly checkpoint, and the maintenance of chromosomal stability. A design based on JNK inhibitors with an aminopyridine scaffold and subse...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Kusakabe, Ken-ichi, Ide, Nobuyuki, Daigo, Yataro, Itoh, Takeshi, Higashino, Kenichi, Okano, Yousuke, Tadano, Genta, Tachibana, Yuki, Sato, Yuji, Inoue, Makiko, Wada, Tooru, Iguchi, Motofumi, Kanazawa, Takayuki, Ishioka, Yukichi, Dohi, Keiji, Tagashira, Sachie, Kido, Yasuto, Sakamoto, Shingo, Yasuo, Kazuya, Maeda, Masahiro, Yamamoto, Takahiko, Higaki, Masayo, Endoh, Takeshi, Ueda, Kazuo, Shiota, Takeshi, Murai, Hitoshi, Nakamura, Yusuke
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025729/
https://ncbi.nlm.nih.gov/pubmed/24900510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000879
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados