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Mechanism of Inhibition of the GluA1 AMPA Receptor Channel Opening by the 2,3-Benzodiazepine Compound GYKI 52466 and a N-Methyl-Carbamoyl Derivative

[Image: see text] 2,3-Benzodiazepine derivatives, also known as GYKI compounds, represent a group of the most promising synthetic inhibitors of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Here we investigate the mechanism of inhibition of the GluA1 channel opening and the...

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Autors principals: Wu, Andrew, Wang, Congzhou, Niu, Li
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2014
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025570/
https://ncbi.nlm.nih.gov/pubmed/24738995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5002079
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