Sesquiterpene Lactone in Nanostructured Parenteral Dosage Form Is Efficacious in Experimental Chagas Disease

The drugs available for Chagas disease treatment are toxic and ineffective. We studied the in vivo activity of a new drug, lychnopholide (LYC). LYC was loaded in nanocapsules (NC), and its effects were compared to free LYC and benznidazole against Trypanosoma cruzi. Infected mice were treated in the...

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Autors principals: Branquinho, Renata Tupinambá, Mosqueira, Vanessa Carla Furtado, de Oliveira-Silva, Jaquelline Carla Valamiel, Simões-Silva, Marianne Rocha, Saúde-Guimarães, Dênia Antunes, de Lana, Marta
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2014
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023798/
https://ncbi.nlm.nih.gov/pubmed/24449777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00617-13
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