Pharmacological Properties of NAI-603, a Well-Tolerated Semisynthetic Derivative of Ramoplanin

NAI-603 is a ramoplanin derivative designed to overcome the tolerability issues of the parent drug as a systemic agent. NAI-603 is highly active against aerobic and anaerobic Gram-positive bacteria, with MICs ranging from 0.008 to 8 μg/ml. MICs were not significantly affected by pH (range, 6 to 8),...

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Bibliografiske detaljer
Main Authors: Jabes, Daniela, Brunati, Cristina, Candiani, GianPaolo, Riva, Simona, Romanó, Gabriella, Maffioli, Sonia, Rossi, Rosaria, Simone, Matteo, Gaspari, Eleonora, Donadio, Stefano
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023767/
https://ncbi.nlm.nih.gov/pubmed/24419352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01620-13
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