Epicutaneously applied Der p 2 induces a strong T(H)2-biased antibody response in C57BL/6 mice, independent of functional TLR4

BACKGROUND: The major house dust mite allergen Der p 2 is a structural and functional homologue of MD-2 within the TLR4–CD14–MD-2 complex. An asthma mouse model in TLR4-deficient mice recently suggested that the allergic immune response against Der p 2 is solely dependent on TLR4 signaling. We inves...

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Main Authors: Stremnitzer, C, Manzano-Szalai, K, Starkl, P, Willensdorfer, A, Schrom, S, Singer, J, Reichart, U, Akira, S, Jensen-Jarolim, E
格式: Artigo
語言:Inglês
出版: BlackWell Publishing Ltd 2014
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023119/
https://ncbi.nlm.nih.gov/pubmed/24735481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/all.12399
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