Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge

BACKGROUND: Enterovirus 71 (EV71) is the etiologic agent of hand-foot-and-mouth disease (HFMD) in the Asia-Pacific region, Many strategies have been applied to develop EV71 vaccines but no vaccines are currently available. Mucosal immunization of the VP1, a major immunogenic capsid protein of EV71,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zhang, Fushun, Hao, Chunsheng, Zhang, Shuo, Li, Aqian, Zhang, Quanfu, Wu, Wei, Liu, Lin, Li, Chuan, Liang, Mifang, Li, Xiuling, Li, Dexin
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022980/
https://ncbi.nlm.nih.gov/pubmed/24885121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-11-80
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