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Dennd3 Functions as a Guanine Nucleotide Exchange Factor for Small GTPase Rab12 in Mouse Embryonic Fibroblasts

Small GTPase Rab12 regulates mTORC1 (mammalian target of rapamycin complex 1) activity and autophagy through controlling PAT4 (proton/amino acid transporter 4) trafficking from recycling endosomes to lysosomes, where PAT4 is degraded. However, the precise regulatory mechanism of the Rab12-mediated m...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Matsui, Takahide, Noguchi, Kenta, Fukuda, Mitsunori
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022869/
https://ncbi.nlm.nih.gov/pubmed/24719330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.546689
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