The Downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 Axis and by Human Cytomegalovirus (HCMV) Associated Factors Allows the Activation of the HCMV Major IE Promoter and the Transition to Productive Infection

Earlier studies had suggested that epigenetic mechanisms play an important role in the control of human cytomegalovirus (HCMV) infection. Here we show that productive HCMV infection is indeed under the control of histone H3K27 trimethylation. The histone H3K27 methyltransferase EZH2, and its regulat...

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Detalhes bibliográficos
Main Authors: Sourvinos, George, Morou, Antigoni, Sanidas, Ioannis, Codruta, Ignea, Ezell, Scott A., Doxaki, Christina, Kampranis, Sotirios C., Kottakis, Filippos, Tsichlis, Philip N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022736/
https://ncbi.nlm.nih.gov/pubmed/24830456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004136
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