Structural and Biochemical Characterization Reveals LysGH15 as an Unprecedented “EF-Hand-Like” Calcium-Binding Phage Lysin

The lysin LysGH15, which is derived from the staphylococcal phage GH15, demonstrates a wide lytic spectrum and strong lytic activity against methicillin-resistant Staphylococcus aureus (MRSA). Here, we find that the lytic activity of the full-length LysGH15 and its CHAP domain is dependent on calciu...

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Detalhes bibliográficos
Main Authors: Gu, Jingmin, Feng, Yingang, Feng, Xin, Sun, Changjiang, Lei, Liancheng, Ding, Wei, Niu, Fengfeng, Jiao, Lianying, Yang, Mei, Li, Yue, Liu, Xiaohe, Song, Jun, Cui, Ziyin, Han, Dong, Du, Chongtao, Yang, Yongjun, Ouyang, Songying, Liu, Zhi-Jie, Han, Wenyu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022735/
https://ncbi.nlm.nih.gov/pubmed/24831957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004109
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