Abnormal Interactions between Perifollicular Mast Cells and CD8+ T-Cells May Contribute to the Pathogenesis of Alopecia Areata

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are crucial immunomodulatory cells implicated in the regulation of T cell-dependent immunity, IP, and hair growth. Therefo...

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Autors principals: Bertolini, Marta, Zilio, Federica, Rossi, Alfredo, Kleditzsch, Patrick, Emelianov, Vladimir E., Gilhar, Amos, Keren, Aviad, Meyer, Katja C., Wang, Eddy, Funk, Wolfgang, McElwee, Kevin, Paus, Ralf
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4022513/
https://ncbi.nlm.nih.gov/pubmed/24832234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0094260
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