Cot/tpl2 participates in the activation of macrophages by adiponectin

Whereas the main function of APN is to enhance insulin activity, it is also involved in modulating the macrophage phenotype. Here, we demonstrate that at physiological concentrations, APN activates Erk1/2 via the IKKβ-p105/NF-κΒ1-Cot/tpl2 intracellular signal transduction cassette in macrophages. In...

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Bibliografske podrobnosti
Main Authors: Sanz-Garcia, Carlos, Nagy, Laura E., Lasunción, Miguel A., Fernandez, Margarita, Alemany, Susana
Format: Artigo
Jezik:Inglês
Izdano: Society for Leukocyte Biology 2014
Teme:
Receptors, Signal Transduction, & Genes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021433/
https://ncbi.nlm.nih.gov/pubmed/24532642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0913486
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