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Cot/tpl2 participates in the activation of macrophages by adiponectin
Whereas the main function of APN is to enhance insulin activity, it is also involved in modulating the macrophage phenotype. Here, we demonstrate that at physiological concentrations, APN activates Erk1/2 via the IKKβ-p105/NF-κΒ1-Cot/tpl2 intracellular signal transduction cassette in macrophages. In...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Society for Leukocyte Biology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4021433/ https://ncbi.nlm.nih.gov/pubmed/24532642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0913486 |
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