Cot/tpl2 participates in the activation of macrophages by adiponectin

Whereas the main function of APN is to enhance insulin activity, it is also involved in modulating the macrophage phenotype. Here, we demonstrate that at physiological concentrations, APN activates Erk1/2 via the IKKβ-p105/NF-κΒ1-Cot/tpl2 intracellular signal transduction cassette in macrophages. In...

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Bibliografiske detaljer
Main Authors: Sanz-Garcia, Carlos, Nagy, Laura E., Lasunción, Miguel A., Fernandez, Margarita, Alemany, Susana
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2014
Fag:
Receptors, Signal Transduction, & Genes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021433/
https://ncbi.nlm.nih.gov/pubmed/24532642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0913486
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