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Cot/tpl2 participates in the activation of macrophages by adiponectin

Whereas the main function of APN is to enhance insulin activity, it is also involved in modulating the macrophage phenotype. Here, we demonstrate that at physiological concentrations, APN activates Erk1/2 via the IKKβ-p105/NF-κΒ1-Cot/tpl2 intracellular signal transduction cassette in macrophages. In...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Sanz-Garcia, Carlos, Nagy, Laura E., Lasunción, Miguel A., Fernandez, Margarita, Alemany, Susana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Leukocyte Biology 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4021433/
https://ncbi.nlm.nih.gov/pubmed/24532642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0913486
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