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Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation
BACKGROUND: Iron may damage sarcomeric proteins through oxidative stress. We explored the left ventricular (LV) torsional mechanics in patients with beta-thalassaemia major and its relationship to myocardial iron load. Using HL-1 cell and B6D2F1 mouse models, we further determined the impact of iron...
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| Principais autores: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4021258/ https://ncbi.nlm.nih.gov/pubmed/24725620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2261-14-49 |
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