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Enzyme replacement therapy on hypophosphatasia mouse model
Hypophosphatasia (HPP) is an inborn error of metabolism caused by deficiency of the tissue-nonspecific alkaline phosphatase (TNSALP), resulting in a defect of bone mineralization. Natural substrates for this ectoenzyme accumulate extracellulary including inorganic pyrophosphate (PPi), an inhibitor o...
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| Main Authors: | , , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4020913/ https://ncbi.nlm.nih.gov/pubmed/23978959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-013-9646-7 |
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