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Evaluation of Toxicogenomics Approaches for Assessing the Risk of Nongenotoxic Carcinogenicity in Rat Liver

The current gold-standard method for cancer safety assessment of drugs is a rodent two-year bioassay, which is associated with significant costs and requires testing a high number of animals over lifetime. Due to the absence of a comprehensive set of short-term assays predicting carcinogenicity, new...

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Autors principals: Eichner, Johannes, Wrzodek, Clemens, Römer, Michael, Ellinger-Ziegelbauer, Heidrun, Zell, Andreas
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020844/
https://ncbi.nlm.nih.gov/pubmed/24828355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097678
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