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Synthesis and Reactivity Comparisons of 1-Methyl-3-Substituted Cyclopropene Mini-tags for Tetrazine Bioorthogonal Reactions

Substituted cyclopropenes have recently attracted attention as stable “mini-tags” that are highly reactive dienophiles with the bioorthogonal tetrazine functional group. Despite this interest, the synthesis of stable cyclopropenes is not trivial and their reactivity patterns are poorly understood. H...

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Detalhes bibliográficos
Main Authors: Yang, Jun, Liang, Yong, Šečkutė, Jolita, Houk, K. N., Devaraj, Neal K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020353/
https://ncbi.nlm.nih.gov/pubmed/24615990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201304225
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