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Hypermutable DNA chronicles the evolution of human colon cancer

Intratumor genetic heterogeneity reflects the evolutionary history of a cancer and is thought to influence treatment outcomes. Here we report that a simple PCR-based assay interrogating somatic variation in hypermutable polyguanine (poly-G) repeats can provide a rapid and reliable assessment of mito...

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Detalhes bibliográficos
Main Authors: Naxerova, Kamila, Brachtel, Elena, Salk, Jesse J., Seese, Aaron M., Power, Karen, Abbasi, Bardia, Snuderl, Matija, Chiang, Sarah, Kasif, Simon, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4020055/
https://ncbi.nlm.nih.gov/pubmed/24753616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400179111
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