Very small size proteoliposomes abrogate cross-presentation of tumor antigens by myeloid-derived suppressor cells and induce their differentiation to dendritic cells

BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are among the major obstacles that adjuvants for cancer vaccines have to overcome. These cells cross-present tumor-associated antigens (TAA) to naive T lymphocytes with a tolerogenic outcome. Very Small Size Proteoliposomes (VSSP) is used as adjuv...

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Hlavní autoři: Fernández, Audry, Oliver, Liliana, Alvarez, Rydell, Hernández, Arletty, Raymond, Judith, Fernández, Luis E, Mesa, Circe
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2014
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019907/
https://ncbi.nlm.nih.gov/pubmed/24829762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-2-5
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