Immunologic responses to xenogeneic tyrosinase DNA vaccine administered by electroporation in patients with malignant melanoma

BACKGROUND: Prior studies show that intramuscular injection and particle-mediated epidermal delivery of xenogeneic melanosomal antigens (tyrosinase or Tyr, gp100) induce CD8(+) T cell responses to the syngeneic protein. To further define the optimal vaccination strategy, we conducted a phase I study...

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Autores principales: Yuan, Jianda, Ku, Geoffrey Y, Adamow, Matthew, Mu, Zhenyu, Tandon, Sapna, Hannaman, Drew, Chapman, Paul, Schwartz, Gary, Carvajal, Richard, Panageas, Katherine S, Houghton, Alan N, Wolchok, Jedd D
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019903/
https://ncbi.nlm.nih.gov/pubmed/24829756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-1-20
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