A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma

BACKGROUND: CEA is expressed in >90% of pancreatic cancers (PC) and may be an appropriate immunotherapy target. CEA is poorly immunogenic due to immune tolerance; CAP1-6D, an altered peptide ligand can help bypass tolerance. We conducted a pilot randomized phase I trial in PC patients to determin...

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Autori principali: Geynisman, Daniel M, Zha, Yuanyuan, Kunnavakkam, Rangesh, Aklilu, Mebea, Catenacci, Daniel VT, Polite, Blase N, Rosenbaum, Cara, Namakydoust, Azadeh, Karrison, Theodore, Gajewski, Thomas F, Kindler, Hedy L
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019890/
https://ncbi.nlm.nih.gov/pubmed/24829746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-1-8
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