Rational Design of Berberine-Based FtsZ Inhibitors with Broad-Spectrum Antibacterial Activity

Inhibition of the functional activity of Filamenting temperature-sensitive mutant Z (FtsZ) protein, an essential and highly conserved bacterial cytokinesis protein, is a promising approach for the development of a new class of antibacterial agents. Berberine, a benzylisoquinoline alkaloid widely use...

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Bibliografiska uppgifter
Huvudupphovsmän: Sun, Ning, Chan, Fung-Yi, Lu, Yu-Jing, Neves, Marco A. C., Lui, Hok-Kiu, Wang, Yong, Chow, Ka-Yan, Chan, Kin-Fai, Yan, Siu-Cheong, Leung, Yun-Chung, Abagyan, Ruben, Chan, Tak-Hang, Wong, Kwok-Yin
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019636/
https://ncbi.nlm.nih.gov/pubmed/24824618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097514
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