Extracellular Matrix Regulates UNC-6 (Netrin) Axon Guidance by Controlling the Direction of Intracellular UNC-40 (DCC) Outgrowth Activity

How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral source of secreted UNC-6 (netrin). The axon’s outgrowth response to UNC-6 is mediated by the UNC-40 (DCC) receptor. We have proposed that in r...

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Bibliographic Details
Main Authors: Yang, Yong, Lee, Won Suk, Tang, Xia, Wadsworth, William G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019552/
https://ncbi.nlm.nih.gov/pubmed/24824544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097258
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