Clostridium difficile Extracytoplasmic Function σ Factor σ(V) Regulates Lysozyme Resistance and Is Necessary for Pathogenesis in the Hamster Model of Infection

Clostridium difficile is a clinically important pathogen and the most common cause of hospital-acquired infectious diarrhea. Expression of the C. difficile gene csfV, which encodes σ(V), an extracytoplasmic function σ factor, is induced by lysozyme, which damages the peptidoglycan of bacteria. Here...

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Autores principales: Ho, Theresa D., Williams, Kyle B., Chen, Yan, Helm, Richard F., Popham, David L., Ellermeier, Craig D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2014
Materias:
Molecular Pathogenesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4019185/
https://ncbi.nlm.nih.gov/pubmed/24664503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01483-13
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