Development and Optimization of a High-Throughput Assay To Measure Neutralizing Antibodies against Clostridium difficile Binary Toxin

Clostridium difficile strains producing binary toxin, in addition to toxin A (TcdA) and toxin B (TcdB), have been associated with more severe disease and increased recurrence of C. difficile infection in recent outbreaks. Binary toxin comprises two subunits (CDTa and CDTb) and catalyzes the ADP-ribo...

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Hlavní autoři: Xie, Jinfu, Horton, Melanie, Zorman, Julie, Antonello, Joseph M., Zhang, Yuhua, Arnold, Beth A., Secore, Susan, Xoconostle, Rachel, Miezeiewski, Matthew, Wang, Su, Price, Colleen E., Thiriot, David, Goerke, Aaron, Gentile, Marie-Pierre, Skinner, Julie M., Heinrichs, Jon H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Diagnostic Laboratory Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018877/
https://ncbi.nlm.nih.gov/pubmed/24623624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00038-14
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