Adenovirus Type 4 and 7 Vaccination or Adenovirus Type 4 Respiratory Infection Elicits Minimal Cross-Reactive Antibody Responses to Nonhuman Adenovirus Vaccine Vectors

Antivector immunity may limit the immunogenicity of adenovirus vector vaccines. We tested sera from individuals immunized with adenovirus type 4 and 7 (Ad4 and Ad7, respectively) vaccine or naturally infected with Ad4 for their ability to neutralize a panel of E1-deleted human and chimpanzee adenovi...

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Main Authors: Paris, Robert, Kuschner, Robert A., Binn, Leonard, Thomas, Stephen J., Colloca, Stefano, Nicosia, Alfredo, Cortese, Riccardo, Bailer, Robert T., Sullivan, Nancy, Koup, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018874/
https://ncbi.nlm.nih.gov/pubmed/24623627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00011-14
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