PI3K-mediated PDGFRα signaling regulates survival and proliferation in skeletal development through p53-dependent intracellular pathways

Previous studies have identified phosphatidylinositol 3-kinase (PI3K) as the main downstream effector of PDGFRα signaling during murine skeletal development. Autophosphorylation mutant knock-in embryos in which PDGFRα is unable to bind PI3K (Pdgfra(PI3K/PI3K)) exhibit skeletal defects affecting the...

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Bibliografiske detaljer
Main Authors: Fantauzzo, Katherine A., Soriano, Philippe
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018488/
https://ncbi.nlm.nih.gov/pubmed/24788519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.238709.114
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