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Microsecond Simulations of DNA and Ion Transport in Nanopores with Novel Ion-Ion and Ion-Nucleotides Effective Potentials

We developed a novel scheme based on the Grand-Canonical Monte-Carlo/Brownian Dynamics (GCMC/BD) simulations and have extended it to studies of ion currents across three nanopores with the potential for ssDNA sequencing: solid-state nanopore Si(3)N(4), α-hemolysin, and E111N/M113Y/K147N mutant. To d...

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Autors principals: De Biase, Pablo M., Markosyan, Suren, Noskov, Sergei
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018453/
https://ncbi.nlm.nih.gov/pubmed/24738152
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