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Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers

We designed two Phase I studies that assessed healthy volunteers in order to evaluate the safety and to optimize the dosing of the combination of the drugs isosorbide dinitrate, a nitric oxide donor, and ibuprofen, a nonsteroidal antiinflammatory drug. We designed these studies with the aim of desig...

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Bibliografski detalji
Glavni autori: Cossu, Maria Vittoria, Cattaneo, Dario, Fucile, Serena, Pellegrino, Paolo, Baldelli, Sara, Cozzi, Valeria, Capetti, Amedeo, Clementi, Emilio
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018313/
https://ncbi.nlm.nih.gov/pubmed/24851040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S58803
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