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Aryltriflates as a Neglected Moiety in Medicinal Chemistry: A Case Study from a Lead Optimization of CXCL8 Inhibitors
[Image: see text] Interleukin-8 and growth related oncogene−α-chemokines (formerly CXCL8 and CXCL1, respectively) mediate chemotaxis of neutrophils to inflammatory sites via interactions with two transmembrane receptors, the type A CXCL8 receptor (CXCR1) and the type B CXCL8 receptor (CXCR2). In a p...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Chemical Society
2011
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| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018143/ https://ncbi.nlm.nih.gov/pubmed/24900265 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001533 |
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