Discovery of a Selective S1P(1) Receptor Agonist Efficacious at Low Oral Dose and Devoid of Effects on Heart Rate

[Image: see text] Gilenya (fingolimod, FTY720) was recently approved by the U.S. FDA for the treatment of patients with remitting relapsing multiple sclerosis (RRMS). It is a potent agonist of four of the five sphingosine 1-phosphate (S1P) G-protein-coupled receptors (S1P(1) and S1P(3−5)). It has be...

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Main Authors: Demont, Emmanuel H., Andrews, Benjamin I., Bit, Rino A., Campbell, Colin A., Cooke, Jason W. B., Deeks, Nigel, Desai, Sapna, Dowell, Simon J., Gaskin, Pam, Gray, James R. J., Haynes, Andrea, Holmes, Duncan S., Kumar, Umesh, Morse, Mary A., Osborne, Greg J., Panchal, Terry, Patel, Bela, Perboni, Alcide, Taylor, Simon, Watson, Robert, Witherington, Jason, Willis, Robert
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2011
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018134/
https://ncbi.nlm.nih.gov/pubmed/24900328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2000214
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