Discovery of AMG 369, a Thiazolo[5,4-b]pyridine Agonist of S1P(1) and S1P(5)

[Image: see text] The optimization of a series of thiazolopyridine S1P(1) agonists with limited activity at the S1P(3) receptor is reported. These efforts resulted in the discovery of 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo-[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid (5d, AMG 369),...

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Autori principali: Cee, Victor J., Frohn, Mike, Lanman, Brian A., Golden, Jennifer, Muller, Kristine, Neira, Susana, Pickrell, Alex, Arnett, Heather, Buys, Janet, Gore, Anu, Fiorino, Mike, Horner, Michelle, Itano, Andrea, Lee, Matt R., McElvain, Michele, Middleton, Scot, Schrag, Michael, Rivenzon-Segal, Dalia, Vargas, Hugo M., Xu, Han, Xu, Yang, Zhang, Xuxia, Siu, Jerry, Wong, Min, Bürli, Roland W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2010
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018127/
https://ncbi.nlm.nih.gov/pubmed/24900288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100306h
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