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Target Flexibility in RNA−Ligand Docking Modeled by Elastic Potential Grids

[Image: see text] The highly flexible nature of RNA provides a formidable challenge for structure-based drug design approaches that target RNA. We introduce an approach for modeling target conformational changes in RNA−ligand docking based on potential grids that are represented as elastic bodies us...

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Main Authors: Krüger, Dennis M., Bergs, Johannes, Kazemi, Sina, Gohlke, Holger
格式: Artigo
語言:Inglês
出版: American Chemical Society 2011
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018104/
https://ncbi.nlm.nih.gov/pubmed/24900336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100217h
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