Synthesis of Marine-Derived 3-Alkylpyridinium Alkaloids with Potent Antiprotozoal Activity

[Image: see text] Given the pressing need for new antiprotozoal drugs without cross-resistance with current (failing) chemotherapy, we have explored 3-tridecylpyridinium alkaloids (3TPAs), derivatives of viscosamine, as antiparasitic agents. We have developed a simple synthetic route toward viscosam...

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Autori principali: Rodenko, Boris, Al-Salabi, Mohammed I., Teka, Ibrahim A., Ho, William, El-Sabbagh, Nasser, Ali, Juma A. M., Ibrahim, Hasan M. S., Wanner, Martin J., Koomen, Gerrit-Jan, de Koning, Harry P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2011
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018069/
https://ncbi.nlm.nih.gov/pubmed/24900279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200160k
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