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Rigid Analogues of Antimitotic Indolobenzazepinones: New Insights into Tubulin Binding via Molecular Modeling
[Image: see text] Two rigid analogues of 5-ethylindolobenzazepinone 4, a potent cytotoxic agent and inhibitor of tubulin polymerization, were prepared. The first was the indane derivative 5, in which the ethyl group is attached to the benzo moiety. The second was the pyrrolidine analogue 6, in which...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
American Chemical Society
2011
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4018049/ https://ncbi.nlm.nih.gov/pubmed/24900350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200024y |
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