The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor

[Image: see text] The synthesis of novel, selective, orally active 2,5-disubstituted 6H-pyrimido[1,6-b]pyridazin-6-one p38α inhibitors is described. Application of structural information from enzyme–ligand complexes guided the selection of screening compounds, leading to the identification of a nove...

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Detalhes bibliográficos
Main Authors: Duffy, John P., Harrington, Edmund M., Salituro, Francesco G., Cochran, John E., Green, Jeremy, Gao, Huai, Bemis, Guy W., Evindar, Ghotas, Galullo, Vincent P., Ford, Pamella J., Germann, Ursula A., Wilson, Keith P., Bellon, Steven F., Chen, Guanging, Taslimi, Paul, Jones, Peter, Huang, Cassey, Pazhanisamy, S., Wang, Yow-Ming, Murcko, Mark A., Su, Michael S.S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4018046/
https://ncbi.nlm.nih.gov/pubmed/24900264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2001455
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