Benzofuran Derivatives as Potent, Orally Active S1P(1) Receptor Agonists: A Preclinical Lead Molecule for MS

[Image: see text] We have discovered novel benzofuran-based S1P(1) agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P(1) agonist with >1000× selectivity over S1P(3). It demonstrated a go...

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Main Authors: Saha, Ashis K., Yu, Xiang, Lin, Jian, Lobera, Mercedes, Sharadendu, Anurag, Chereku, Srinivas, Schutz, Nili, Segal, Dalia, Marantz, Yael, McCauley, Dilara, Middleton, Scot, Siu, Jerry, Bürli, Roland W., Buys, Janet, Horner, Michelle, Salyers, Kevin, Schrag, Michael, Vargas, Hugo M., Xu, Yang, McElvain, Michele, Xu, Han
格式: Artigo
語言:Inglês
出版: American Chemical Society 2010
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017978/
https://ncbi.nlm.nih.gov/pubmed/24900286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100227q
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