Benzofuran Derivatives as Potent, Orally Active S1P(1) Receptor Agonists: A Preclinical Lead Molecule for MS

[Image: see text] We have discovered novel benzofuran-based S1P(1) agonists with excellent in vitro potency and selectivity. 1-((4-(5-Benzylbenzofuran-2-yl)-3-fluorophenyl)methyl) azetidine-3-carboxylic acid (18) is a potent S1P(1) agonist with >1000× selectivity over S1P(3). It demonstrated a go...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Saha, Ashis K., Yu, Xiang, Lin, Jian, Lobera, Mercedes, Sharadendu, Anurag, Chereku, Srinivas, Schutz, Nili, Segal, Dalia, Marantz, Yael, McCauley, Dilara, Middleton, Scot, Siu, Jerry, Bürli, Roland W., Buys, Janet, Horner, Michelle, Salyers, Kevin, Schrag, Michael, Vargas, Hugo M., Xu, Yang, McElvain, Michele, Xu, Han
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2010
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017978/
https://ncbi.nlm.nih.gov/pubmed/24900286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100227q
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