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Linking a genetic defect in migraine to spreading depression in a computational model
Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. A mutation causing FHM type 3 (FHM3) has been identified in SCN1A encoding the Nav1.1 Na(+) channel. This genetic defect affects the inactivation gate. While the Na(+) tail currents following voltage steps are consistent wit...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
PeerJ Inc.
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017887/ https://ncbi.nlm.nih.gov/pubmed/24860703 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7717/peerj.379 |
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