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Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating
RATIONALE: Inhibitors of phosphodiesterase 10A (PDE10A), an enzyme highly expressed in medium spiny neurons of the mammalian striatum, enhance activity in direct, dopamine D1 receptor-expressing and indirect, D2 receptor-expressing striatal output pathways. The ability of such agents to act to poten...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4017785/ https://ncbi.nlm.nih.gov/pubmed/24363077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-013-3371-7 |
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