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p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes

Deregulated expression of COX-2 has been causally linked to development, progression, and outcome of several types of human cancer. We describe a novel fundamental level of transcriptional control of COX-2 expression. Using primary human mammary epithelial cells and monocyte/macrophage cell lines, w...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Krawczyk, Michal, Emerson, Beverly M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017649/
https://ncbi.nlm.nih.gov/pubmed/24843008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01776
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