Ammonia Control in Children Ages 2 Months through 5 Years with Urea Cycle Disorders: Comparison of Sodium Phenylbutyrate and Glycerol Phenylbutyrate

OBJECTIVES: To examine ammonia levels, pharmacokinetics (PK), and safety of glycerol phenylbutyrate (GPB, HPN-100) and sodium phenylbutyrate (NaPBA) in young children with urea cycle disorders (UCDs). STUDY DESIGN: This open label switch-over study enrolled patients ages 29 days to under 6 years tak...

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Main Authors: Smith, W, Diaz, GA, Lichter-Konecki, U, Berry, SA, Harding, CO, McCandless, SE, LeMons, C, Mauney, J, Dickinson, K, Coakley, DF, Moors, TL, Mokhtarani, M, Scharschmidt, BF, Lee, B
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4017326/
https://ncbi.nlm.nih.gov/pubmed/23324524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpeds.2012.11.084
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