Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Cancer-secreted miRNAs are emerging mediators of cancer–host crosstalk. Here we show that miR-105, which is characteristically expressed and secreted by metastatic breast cancer cells, is a potent regulator of migration through targeting the tight junction protein ZO-1. In endothelial monolayers, ex...

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Hauptverfasser: Zhou, Weiying, Fong, Miranda Y., Min, Yongfen, Somlo, George, Liu, Liang, Palomares, Melanie R., Yu, Yang, Chow, Amy, O’Connor, Sean Timothy Francis, Chin, Andrew R., Yen, Yun, Wang, Yafan, Marcusson, Eric G., Chu, Peiguo, Wu, Jun, Wu, Xiwei, Li, Arthur Xuejun, Li, Zhuo, Gao, Hanlin, Ren, Xiubao, Boldin, Mark P., Lin, Pengnian Charles, Wang, Shizhen Emily
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4016197/
https://ncbi.nlm.nih.gov/pubmed/24735924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.03.007
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