The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells

BACKGROUND: In the present study we determined the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly e...

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Detalhes bibliográficos
Main Authors: Leibovich-Rivkin, Tal, Liubomirski, Yulia, Meshel, Tsipi, Abashidze, Anastasia, Brisker, Daphna, Solomon, Hilla, Rotter, Varda, Weil, Miguel, Ben-Baruch, Adit
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015419/
https://ncbi.nlm.nih.gov/pubmed/24598028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-158
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