The genomic landscape of mantle cell lymphoma is related to the epigenetically determined chromatin state of normal B cells

In this study, we define the genetic landscape of mantle cell lymphoma (MCL) through exome sequencing of 56 cases of MCL. We identified recurrent mutations in ATM, CCND1, MLL2, and TP53. We further identified a number of novel genes recurrently mutated in patients with MCL including RB1, WHSC1, POT1...

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Hlavní autoři: Zhang, Jenny, Jima, Dereje, Moffitt, Andrea B., Liu, Qingquan, Czader, Magdalena, Hsi, Eric D., Fedoriw, Yuri, Dunphy, Cherie H., Richards, Kristy L., Gill, Javed I., Sun, Zhen, Love, Cassandra, Scotland, Paula, Lock, Eric, Levy, Shawn, Hsu, David S., Dunson, David, Dave, Sandeep S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014841/
https://ncbi.nlm.nih.gov/pubmed/24682267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-07-517177
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