D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine

D-amino acid oxidase (DAO, DAAO) degrades the NMDA receptor co-agonist D-serine, modulating D-serine levels and thence NMDA receptor function. DAO inhibitors are under development as a therapy for schizophrenia, a disorder involving both NMDA receptor and dopaminergic dysfunction. However, a direct...

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Detalhes bibliográficos
Main Authors: Betts, Jill F., Schweimer, Judith V., Burnham, Katherine E., Burnet, Philip W. J., Sharp, Trevor, Harrison, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014674/
https://ncbi.nlm.nih.gov/pubmed/24822045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnsyn.2014.00011
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