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Pro32Pro33 Mutations in the Integrin β(3) PSI Domain Result in αIIbβ(3) Priming and Enhanced Adhesion: Reversal of the Hypercoagulability Phenotype by the Src Inhibitor SKI-606
The plasma-membrane integrin αIIbβ(3) (CD41/CD61, GPIIbIIIa) is a major functional receptor in platelets during clotting. A common isoform of integrin β(3), Leu33Pro is associated with enhanced platelet function and increased risk for coronary thrombosis and stroke, although these findings remain co...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4014669/ https://ncbi.nlm.nih.gov/pubmed/24695082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.091736 |
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