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Augmented Osteogenic Responses in Human Aortic Valve Cells Exposed to oxLDL and TLR4 Agonist: A Mechanistic Role of Notch1 and NF-κB Interaction
Aortic valve calcification causes the progression of calcific aortic valve disease (CAVD). Stimulation of aortic valve interstitial cells (AVICs) with lipopolysaccharide (LPS) up-regulates the expression of osteogenic mediators, and NF-κB plays a central role in mediating AVIC osteogenic responses t...
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Main Authors: | , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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Public Library of Science
2014
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4014478/ https://ncbi.nlm.nih.gov/pubmed/24810405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0095400 |
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