Timed Action of IL-27 Protects from Immunopathology while Preserving Defense in Influenza

Infection with influenza virus can result in massive pulmonary infiltration and potentially fatal immunopathology. Understanding the endogenous mechanisms that control immunopathology could provide a key to novel adjunct therapies for this disease. Here we show that the cytokine IL-27 plays a crucia...

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Bibliographic Details
Main Authors: Liu, Francesca Diane M., Kenngott, Elisabeth E., Schröter, Micha F., Kühl, Anja, Jennrich, Silke, Watzlawick, Ralf, Hoffmann, Ute, Wolff, Thorsten, Norley, Stephen, Scheffold, Alexander, Stumhofer, Jason S., Saris, Christiaan J. M., Schwab, Jan M., Hunter, Christopher A., Debes, Gudrun F., Hamann, Alf
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014457/
https://ncbi.nlm.nih.gov/pubmed/24809349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004110
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